Secondary Bile Acids

Secondary bile acids (BAs) are produced from primary BAs (e.g., deoxycholic acid from cholic acid) by microbiota in the intestine and can be conjugated with glycine or taurine in the liver.  Similar to the primary BAs, the secondary bile acids also possess numerous biological functions (e.g., signaling molecules) and have been studied for a variety of purposes (e.g., biomarkers of liver function, BA synthesis/metabolism).  CIL offers a plethora of unconjugated (e.g., deoxycholic acid or DCA, lithocholic acid or LCA) and conjugated (e.g., taurodeoxycholic acid or TDCA, glycolithocholic acid or GLCA) secondary BAs toward research explorations in this space.  These are available in their stable isotope-labeled and unlabeled form as solution or neat materials for research use purposes.  A few secondary BAs (3 unconjugated and 6 conjugated) are also included in our BA mixtures (stable isotope-labeled: MSK-BA1 and MSK-BA2; unlabeled: MSK-BA1-US and MSK-BA2-US).

For additional information on these standards and mixes, please see our Stable Isotope Standards for Mass Spectrometry catalog and Metabolomics Bile Acid Mixtures product flyer.