TCA Cycle

The tricarboxylic acid (TCA) cycle, also known as the Krebs or citric acid cycle, plays an essential role in cellular metabolism.  Its pathway comprises eight steps that involve a series of reactions starting with acetyl-CoA, the oxidative end product of the glycolysis pathway, and concluding with oxaloacetate.  Biologically, the TCA cycle constitutes a major production source of cellular ATP and occurs in the mitochondrial matrix in eukaryotes or the cytoplasm in prokaryotes.  To complement the qualitative/quantitative analysis of the TCA cycle in metabolomics- or metabolism-related initiatives, CIL is pleased to offer its intermediates  (e.g., citrate, a-ketoglutarate, succinate, malate) and its side products (e.g., malonate, itaconate, methylcitrate) in their stable isotope-labeled form.  These polar, central carbon metabolites are available in research grade as neat materials.

For additional information, please see our Stable Isotope Standards for Mass Spectrometry catalog.